Guanfacine (Coming Soon)

Lift the fog and clear your mind

Restore your cognitive function and clear your thoughts with guanfacine, an FDA-approved medication offering promise to those with brain fog associated with Long COVID, ME/CFS, and dysautonomia.

We are still working on this medication, sign up for early access!

Clear cognition

Guanfacine acts directly to modulate the activity of the prefrontal cortex, helping to improve memory, attention, and cognitive dysfunction commonly seen with Long COVID and other complex illnesses.

Improving hypertension

Guanfacine is FDA-approved for the treatment of hypertension, or high blood pressure as it works to decrease the heart rate and relax blood vessels, allowing the blood to flow more easily through the body.

Addressing distractibility

Guanfacine helps reduce symptoms such as hyperactivity, impulsiveness, and distractibility commonly seen with attention deficit hyperactivity disorder (ADHD) while also increasing attention.

Learn more about guanfacine

Brain Fog

Poor cognition

Cognitive dysfunction

Hypertension

Fatigue

Hyperactivity

FDA-approved for the treatment of hypertension and ADHD, guanfacine is emerging as an effective treatment for cognitive dysfunction, or brain fog.

As a common symptom for those with Long COVID and ME/CFS, this dysfunction can greatly impact quality of life.

  • Guanfacine's ability to modulate the activity of the prefrontal cortex — an area of the brain involved in attention, working memory, and impulse control — is the basis for its off-label use in conditions such as PTSD, traumatic brain injury, ME/CFS, and now, Long COVID. The drug's action on alpha-2A adrenergic receptors in the brain is thought to potentially improve the cognitive symptoms experienced by some patients with these conditions.

  • Cognitive dysfunction, and even brain fog, are terms that refer to numerous symptoms affecting your daily function. Guanfacine can help address these often frustrating symptoms including:

    • Forgetfulness

    • Loss of words

    • Confusion

    • Inability to follow a conversation

    • Losing train of thought

    • Inability to concentrate

    • Unable to understand words

    • Difficulty finishing tasks

  • While guanfacine is safe and generally well-tolerated by patients, there can be mild side effects:

    • Sleepiness

    • Drowsiness

    • Dizziness

    • Headache

    • Irritability

    • Low blood pressure

    • Nausea

    • Stomach pain

    • Dry mouth

    • Constipation

    • Decreased appetite

    • Confusion

Ready to try guanfacine?

Take advantage of guanfacine in three easy steps.

Fill out a condition assessment.

1

Share your symptoms, current conditions, allergies and complete a health assessment.

Our clinicians will review your health profile.

2

An expert clinician from RTHM Direct will review your assessment within 1 business day and prescribe the requested medication if it is a good fit for your case. Pay $0 unless medication is prescribed.

Get approved and pick-up your prescription.

3

Pick up and pay for the prescribed treatments at your preferred pharmacy using the coupon card we provide.

Pricing

Guanfacine

Online Consultation

90-days supply of medication

$59

Total

Pay at pharmacy

$59.00

RTHM patient voices 

“RTHM has given me hope. After struggling with Long COVID for two years, even with the help of a Long COVID clinic, I was still doing all of my own research and trying to keep my doctors advised of the state of the art in treatments.”

— Stuart S.

How do RTHM clinicians prescribe guanfacine?

Every patient’s journey towards health is unique, especially when managing chronic, complex conditions like Long COVID and ME/CFS. That is why we start patients at lower doses and gradually increase them to find the most effective dose with the fewest side effects.

If you are taking guanfacine for the first time, you will initially receive a 30-day prescription at the lower dose along with clear instructions on how to safely increase your dosage. Once you find your stable dose, you will receive a 60-day prescription at this stable dose.

If you have already found your stable dose of guanfacine, you will have the option to receive a 90-day supply of medication.

Safety is our top priority

The eligibility criteria, the dosing protocols and the treatment guides for every treatment offered via RTHM Direct have been designed by a team of clinicians and pharmacists focused on complex illnesses.

As we continue to navigate the complexities of Long COVID, ME/CFS, and other chronic conditions, we are upholding the highest patient safety standards while expanding access to treatments.

And in case you missed anything.

  • Guanfacine is emerging as an effective treatment for cognitive dysfunction, or brain fog. As a common symptom for those with Long COVID and ME/CFS, this dysfunction can be life-altering.

    • Guanfacine should be used with caution and regular monitoring in patients with the following medical conditions:

      • Structural cardiac abnormalities

      • History of bradycardia (slow heart rate)

      • Depression

      • History of heart attacks

      • Heart rhythm abnormalities

      • Hypotension (low blood pressure)

      • Kidney failure

      • History of stroke

      • Fainting history

      • Kidney disease

      • Liver disease

  • Your guanfacine prescription will likely start with a lower dose and allow for an upward taper until you reach your optimal dose. Because guanfacine can cause drowsiness, it is best taken before bed.

  • If you miss a dose of guanfacine, skip the missed dose and resume your regular dosing schedule. Do not double dose.

  • While guanfacine is safe and generally well-tolerated by patients, there can be mild side effects:

    • Sleepiness

    • Drowsiness

    • Dizziness

    • Headache

    • Irritability

    • Low blood pressure

    • Nausea

    • Stomach pain

    • Dry mouth

    • Constipation

    • Decreased appetite

    • Confusion

  • Keep this medication in the container provided by the pharmacy. Ensure it is properly closed and out of the reach of children. Store at room temperature and away from excess heat and moisture (not in the bathroom).

  • Our selected medications are low-risk and research-backed to improve symptoms of chronic complex conditions.

    Each medication assessment is approved by a team of expert clinicians and pharmacists, ensuring the highest standards of patient safety.