Mast Cell Activation Syndrome (MCAS)
Mast Cell Activation Syndrome (MCAS) is often underdiagnosed due to its diverse clinical presentation and the need for more awareness among healthcare professionals.
The exact prevalence remains uncertain, but estimates suggest that approximately 1% of the population may have some form of mast cell activation disorder with symptoms.
Understanding MCAS
Mast Cell Activation Syndrome (MCAS) is a complex disorder characterized by the inappropriate activation of mast cells, leading to the release of various mediators such as histamine, prostaglandins, and cytokines. These mediators can cause various symptoms affecting multiple organ systems, including skin, gastrointestinal tract, cardiovascular system, and respiratory system.
While there currently is no cure for MCAS, continued research and promising treatments including antihistamines and mast cell stabilizers help patients regain control of their symptoms and see the light ahead.
Autonomic dysfunction
Fatigue
Post-exertional malaise
Sleep disruption
Pain
Brian Fog
Causes of MCAS
Mast Cell Activation Syndrome (MCAS) is like a mix-up in our body’s alarm system. Imagine you have these tiny cells called mast cells, and their job is to react when something goes wrong. But sometimes, they get a bit too excited and start releasing chemicals like histamine, which can cause all sorts of trouble.
Common causes of MCAS can include traditional allergies, such as specific food or pollen but also uncommon triggers such as infections, genetic factors, toxin exposure, nutritional deficiencies, and hormone imbalances.
Common MCAS symptoms
Mast Cell Activation Syndrome (MCAS) can cause a variety of symptoms, affecting different parts of the body. Some common symptoms can include itching, hives, swelling, wheezing, shortness of breath, abdominal pain, diarrhea, brain fog, dermatographism, and widespread pain.
Is MCAS a chronic condition?
There is no cure for Mast Cell Activation Syndrome (MCAS). Still, it is possible to manage symptoms and stabilize the mast cells with medications such as antihistamines and mast cell stabilizers. While there’s no magic fix, early recognition and smart management can keep those overactive mast cells in check and greatly reduce your symptoms.
Read the latest about MCAS from the RTHM team
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And in case you missed anything.
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Mast Cell Activation Syndrome (MCAS) is an immunological condition where mast cells inappropriately and excessively release chemical mediators, such as histamines, leading to a range of chronic symptoms like itching, respiratory, and gastrointestinal upset.
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Symptoms of MCAS can include itching or flushing skin, gastrointestinal discomfort, respiratory symptoms, rapid or irregular heartbeats, brain fog, headaches, fatigue, and muscle and joint pain.
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The exact cause of MCAS is not yet know, though potential underlying causes can include environmental toxins, mold exposure, viral infections, vitamin deficiency, exercise, and significant stress.
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While there are many medications, including over-the-counter options that are approved for reducing histamines and stabilizing mast cells, there are no FDA-approved medications specifically for treating MCAS.
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At this time, RTHM Direct requires a diagnosis from a primary clinician or specialist.
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Treatments for MCAS include mast cell stabilizers, such as cromolyn sodium and H1 and H2 antihistamines, such as Claritin and famotidine.